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ATP7B R778L mutant hepatocytes resist copper toxicity by activating autophagy and inhibiting necroptosis
Wilson’s disease (WD) is an inherited disease characterized by copper metabolism disorder caused by mutations in the adenosine triphosphatase copper transporting β gene (ATP7B). Currently, WD cell and animal model targeting the most common R778L mutation in Asia is lacking. In addition, the mechanis...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505209/ https://www.ncbi.nlm.nih.gov/pubmed/37717021 http://dx.doi.org/10.1038/s41420-023-01641-5 |