Genome-wide analysis of DNA-PK-bound MRN cleavage products supports a sequential model of DSB repair pathway choice

The Mre11-Rad50-Nbs1 (MRN) complex recognizes and processes DNA double-strand breaks for homologous recombination by performing short-range removal of 5ʹ strands. Endonucleolytic processing by MRN requires a stably bound protein at the break site—a role we postulate is played by DNA-dependent protei...

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Detalles Bibliográficos
Autores principales: Deshpande, Rajashree A., Marin-Gonzalez, Alberto, Barnes, Hannah K., Woolley, Phillip R., Ha, Taekjip, Paull, Tanya T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505227/
https://www.ncbi.nlm.nih.gov/pubmed/37717054
http://dx.doi.org/10.1038/s41467-023-41544-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505227/
https://www.ncbi.nlm.nih.gov/pubmed/37717054
http://dx.doi.org/10.1038/s41467-023-41544-8

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