Activation Map Reveals Language Impairment in Children with Benign Epilepsy with Centrotemporal Spikes (BECTS)

OBJECTIVE: Neuropsychological evidence revealed language impairment in children with benign epilepsy with centrotemporal spikes (BECTS). This study investigates language function using task-activated fMRI. METHODS: We conducted a language task fMRI study on three groups on a 3.0T MRI scanner, includ...

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Autores principales: Mo, Tong, Huang, Wenxian, Sun, Weisheng, Hu, Yan, Mcdonald, Leroy, Hu, Zhanqi, Chen, Li, Liao, Jianxiang, Hermann, Bruce, Prabhakaran, Vivek, Zeng, Hongwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505385/
https://www.ncbi.nlm.nih.gov/pubmed/37724160
http://dx.doi.org/10.2147/NDT.S419840
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author Mo, Tong
Huang, Wenxian
Sun, Weisheng
Hu, Yan
Mcdonald, Leroy
Hu, Zhanqi
Chen, Li
Liao, Jianxiang
Hermann, Bruce
Prabhakaran, Vivek
Zeng, Hongwu
author_facet Mo, Tong
Huang, Wenxian
Sun, Weisheng
Hu, Yan
Mcdonald, Leroy
Hu, Zhanqi
Chen, Li
Liao, Jianxiang
Hermann, Bruce
Prabhakaran, Vivek
Zeng, Hongwu
author_sort Mo, Tong
collection PubMed
description OBJECTIVE: Neuropsychological evidence revealed language impairment in children with benign epilepsy with centrotemporal spikes (BECTS). This study investigates language function using task-activated fMRI. METHODS: We conducted a language task fMRI study on three groups on a 3.0T MRI scanner, including a new onset drug naïve group (NODN-BECTS, n=11, age=9.6±1.6), an established epilepsy with medication-treated group (Med-BECTS, n=17, age=10.7±2.2) and a healthy control group (HC, n=18, age=10.8±1.7). We use MATLAB14 and SPM12 to pre-process and analyze the data. A one-sample t-test was used to identify task-related brain activation changes in each group, based on the general linear model (GLM). And, then two sample t-test was performed to compare different activated regions between groups. In addition, scores on the most recent Mandarin school exams were acquired to examine and contrast extra-scanner language performance. RESULTS: Statistical results show that some language-related brain regions (such as the left superior frontal gyrus and cerebellar vermis) were additionally activated in the NODN-BECTS group compared with the HC group. Compared with NODN-BECTS and HC groups, decreased activations were found in language-related regions in the Med-BECTS group, including the left insula, superior and middle frontal gyri, and bilateral middle occipital gyri. On the Mandarin school exams, the average score for HC was 87.3±8.2, NODN was 84.8±7.8, and Med was 78.2±13.2. There was a trend toward statistical significance between the Med and the HC (p = 0.074) as well as NODN (p = 0.092) groups. No statistically significant differences were found between the HC and the NODN-BECTS groups. SIGNIFICANCE: Language task fMRI reveals additional areas of activation in new onset BECTS compared to healthy controls which may be compensatory in nature. Antiseizure medications (ASMs) and/or longer duration of BECTS additionally appears to affect language-related regions and reduce their functional ability.
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spelling pubmed-105053852023-09-18 Activation Map Reveals Language Impairment in Children with Benign Epilepsy with Centrotemporal Spikes (BECTS) Mo, Tong Huang, Wenxian Sun, Weisheng Hu, Yan Mcdonald, Leroy Hu, Zhanqi Chen, Li Liao, Jianxiang Hermann, Bruce Prabhakaran, Vivek Zeng, Hongwu Neuropsychiatr Dis Treat Original Research OBJECTIVE: Neuropsychological evidence revealed language impairment in children with benign epilepsy with centrotemporal spikes (BECTS). This study investigates language function using task-activated fMRI. METHODS: We conducted a language task fMRI study on three groups on a 3.0T MRI scanner, including a new onset drug naïve group (NODN-BECTS, n=11, age=9.6±1.6), an established epilepsy with medication-treated group (Med-BECTS, n=17, age=10.7±2.2) and a healthy control group (HC, n=18, age=10.8±1.7). We use MATLAB14 and SPM12 to pre-process and analyze the data. A one-sample t-test was used to identify task-related brain activation changes in each group, based on the general linear model (GLM). And, then two sample t-test was performed to compare different activated regions between groups. In addition, scores on the most recent Mandarin school exams were acquired to examine and contrast extra-scanner language performance. RESULTS: Statistical results show that some language-related brain regions (such as the left superior frontal gyrus and cerebellar vermis) were additionally activated in the NODN-BECTS group compared with the HC group. Compared with NODN-BECTS and HC groups, decreased activations were found in language-related regions in the Med-BECTS group, including the left insula, superior and middle frontal gyri, and bilateral middle occipital gyri. On the Mandarin school exams, the average score for HC was 87.3±8.2, NODN was 84.8±7.8, and Med was 78.2±13.2. There was a trend toward statistical significance between the Med and the HC (p = 0.074) as well as NODN (p = 0.092) groups. No statistically significant differences were found between the HC and the NODN-BECTS groups. SIGNIFICANCE: Language task fMRI reveals additional areas of activation in new onset BECTS compared to healthy controls which may be compensatory in nature. Antiseizure medications (ASMs) and/or longer duration of BECTS additionally appears to affect language-related regions and reduce their functional ability. Dove 2023-09-13 /pmc/articles/PMC10505385/ /pubmed/37724160 http://dx.doi.org/10.2147/NDT.S419840 Text en © 2023 Mo et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Mo, Tong
Huang, Wenxian
Sun, Weisheng
Hu, Yan
Mcdonald, Leroy
Hu, Zhanqi
Chen, Li
Liao, Jianxiang
Hermann, Bruce
Prabhakaran, Vivek
Zeng, Hongwu
Activation Map Reveals Language Impairment in Children with Benign Epilepsy with Centrotemporal Spikes (BECTS)
title Activation Map Reveals Language Impairment in Children with Benign Epilepsy with Centrotemporal Spikes (BECTS)
title_full Activation Map Reveals Language Impairment in Children with Benign Epilepsy with Centrotemporal Spikes (BECTS)
title_fullStr Activation Map Reveals Language Impairment in Children with Benign Epilepsy with Centrotemporal Spikes (BECTS)
title_full_unstemmed Activation Map Reveals Language Impairment in Children with Benign Epilepsy with Centrotemporal Spikes (BECTS)
title_short Activation Map Reveals Language Impairment in Children with Benign Epilepsy with Centrotemporal Spikes (BECTS)
title_sort activation map reveals language impairment in children with benign epilepsy with centrotemporal spikes (bects)
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505385/
https://www.ncbi.nlm.nih.gov/pubmed/37724160
http://dx.doi.org/10.2147/NDT.S419840
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