Huntingtin CAG-expansion mutation results in a dominant negative effect

Introduction: Huntington’s disease (HD) remains an incurable and fatal neurodegenerative disease long after CAG-expansion mutation in the huntingtin gene (HTT) was identified as the cause. The underlying pathological mechanism, whether HTT loss of function or gain of toxicity results from mutation,...

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Detalles Bibliográficos
Autores principales: Laundos, Tiago L., Li, Shu, Cheang, Eric, De Santis, Riccardo, Piccolo, Francesco M., Brivanlou, Ali H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505792/
https://www.ncbi.nlm.nih.gov/pubmed/37727506
http://dx.doi.org/10.3389/fcell.2023.1252521

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505792/
https://www.ncbi.nlm.nih.gov/pubmed/37727506
http://dx.doi.org/10.3389/fcell.2023.1252521

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