A non‐proteolytic release mechanism for HMCES‐DNA‐protein crosslinks

The conserved protein HMCES crosslinks to abasic (AP) sites in ssDNA to prevent strand scission and the formation of toxic dsDNA breaks during replication. Here, we report a non‐proteolytic release mechanism for HMCES‐DNA‐protein crosslinks (DPCs), which is regulated by DNA context. In ssDNA and at...

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Detalles Bibliográficos
Autores principales: Donsbach, Maximilian, Dürauer, Sophie, Grünert, Florian, Nguyen, Kha T, Nigam, Richa, Yaneva, Denitsa, Weickert, Pedro, Bezalel‐Buch, Rachel, Semlow, Daniel R, Stingele, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505908/
https://www.ncbi.nlm.nih.gov/pubmed/37519246
http://dx.doi.org/10.15252/embj.2022113360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505908/
https://www.ncbi.nlm.nih.gov/pubmed/37519246
http://dx.doi.org/10.15252/embj.2022113360

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