Cargando…

A non‐proteolytic release mechanism for HMCES‐DNA‐protein crosslinks

The conserved protein HMCES crosslinks to abasic (AP) sites in ssDNA to prevent strand scission and the formation of toxic dsDNA breaks during replication. Here, we report a non‐proteolytic release mechanism for HMCES‐DNA‐protein crosslinks (DPCs), which is regulated by DNA context. In ssDNA and at...

Descripción completa

Detalles Bibliográficos
Autores principales:	Donsbach, Maximilian, Dürauer, Sophie, Grünert, Florian, Nguyen, Kha T, Nigam, Richa, Yaneva, Denitsa, Weickert, Pedro, Bezalel‐Buch, Rachel, Semlow, Daniel R, Stingele, Julian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505908/ https://www.ncbi.nlm.nih.gov/pubmed/37519246 http://dx.doi.org/10.15252/embj.2022113360

Ejemplares similares

SPRTN patient variants cause global-genome DNA-protein crosslink repair defects
por: Weickert, Pedro, et al.
Publicado: (2023)

A ubiquitin switch controls autocatalytic inactivation of the DNA–protein crosslink repair protease SPRTN
por: Zhao, Shubo, et al.
Publicado: (2020)

Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition
por: Halabelian, Levon, et al.
Publicado: (2019)

HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation
por: Wu, Lizhen, et al.
Publicado: (2022)

DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease
por: Reinking, Hannah K., et al.
Publicado: (2020)

Protein-oligonucleotide conjugates as model substrates for DNA-protein crosslink repair proteases
por: Reinking, Hannah K., et al.
Publicado: (2021)

Novel mechanisms for the removal of strong replication-blocking HMCES- and thiazolidine-DNA adducts in humans
por: Sugimoto, Yohei, et al.
Publicado: (2023)

Bypass of DNA interstrand crosslinks by a Rev1–DNA polymerase ζ complex
por: Bezalel-Buch, Rachel, et al.
Publicado: (2020)

HMCES Maintains Replication Fork Progression and Prevents Double-Strand Breaks in Response to APOBEC Deamination and Abasic Site Formation
por: Mehta, Kavi P.M., et al.
Publicado: (2020)

Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells
por: Biayna, Josep, et al.
Publicado: (2021)

Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN
por: Stingele, Julian, et al.
Publicado: (2016)

Cellular Cholesterol Distribution Influences Proteolytic Release of the LRP-1 Ectodomain
por: Dekky, Bassil, et al.
Publicado: (2016)

Crosslinked-Polymer Brushes with Switchable Capture and Release Capabilities
por: Demirci, Serkan
Publicado: (2018)

Quantifying the Proteolytic Release of Extracellular Matrix-Sequestered VEGF with a Computational Model
por: Vempati, Prakash, et al.
Publicado: (2010)

Proteolytic maturation of α(2)δ controls the probability of synaptic vesicular release
por: Ferron, Laurent, et al.
Publicado: (2018)

Cell-Based Reporter Release Assay to Determine the Potency of Proteolytic Bacterial Neurotoxins
por: Pathe-Neuschäfer-Rube, Andrea, et al.
Publicado: (2018)

Clinoptilolite Microparticles as Carriers of Catechin-Rich Acacia catechu Extracts: Microencapsulation and In Vitro Release Study
por: Yaneva, Zvezdelina, et al.
Publicado: (2021)

Quercetin-Crosslinked Chitosan Films for Controlled Release of Antimicrobial Drugs
por: Wiggers, Helton José, et al.
Publicado: (2022)

CROSSLINKER CONCENTRATION CONTROLS TGFβ−3 RELEASE AND ANNULUS FIBROSUS CELL APOPTOSIS IN GENIPIN-CROSSLINKED FIBRIN HYDROGELS
por: Panebianco, C.J., et al.
Publicado: (2020)

Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release
por: Li, Wanqiu, et al.
Publicado: (2021)

Pseudomonas aeruginosa Triggered Exosomal Release of ADAM10 Mediates Proteolytic Cleavage in Trans
por: Aljohmani, Ahmad, et al.
Publicado: (2022)

Enhancement of the Controlled-Release Properties of Chitosan Membranes by Crosslinking with Suberoyl Chloride
por: Chen, Chao, et al.
Publicado: (2013)

Dual-Responsive Nanotubes Assembled by Amphiphilic Dendrimers: Controlled Release and Crosslinking
por: Zhang, Minghui, et al.
Publicado: (2020)

Fabrication of Ion-Crosslinking Aminochitosan Nanoparticles for Encapsulation and Slow Release of Curcumin
por: Sun, Xiaoxiao, et al.
Publicado: (2019)

Metalloproteases and Proteolytic Processing
por: Turner, Anthony J., et al.
Publicado: (2010)

The Proteolytic Value of Malt
por: Miller, Charles H.
Publicado: (1899)

Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway
por: Okamoto, Isamu, et al.
Publicado: (2001)

Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF
por: Nanba, Daisuke, et al.
Publicado: (2003)

Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies
por: Linsenmeier, Luise, et al.
Publicado: (2021)

Proteolytic Processing of Angiotensin-I in Human Blood Plasma
por: Hildebrand, Diana, et al.
Publicado: (2013)

MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms
por: Gifford, Valentina, et al.
Publicado: (2019)

The concise encyclopedia of communication
por: Donsbach, Wolfgang
Publicado: (2015)

Proteolytic and non-proteolytic regulation of collective cell invasion: tuning by ECM density and organization
por: Kumar, Sandeep, et al.
Publicado: (2016)

Bioinspired Heparin Nanosponge Prepared by Photo-crosslinking for Controlled Release of Growth Factors
por: Choi, Won Il, et al.
Publicado: (2017)

Role of Polymer Concentration and Crosslinking Density on Release Rates of Small Molecule Drugs
por: Briggs, Francesca, et al.
Publicado: (2022)

dsRNA Binding Domain of PKR Is Proteolytically Released by Enterovirus A71 to Facilitate Viral Replication
por: Chang, Yu-Hsiu, et al.
Publicado: (2017)

Heparan Sulfated Glypican-4 Is Released from Astrocytes by Proteolytic Shedding and GPI-Anchor Cleavage Mechanisms
por: Huang, Kevin, et al.
Publicado: (2021)

The Influence of Proteolytic Malt Modification on the Aging Potential of Final Wort
por: Nobis, Arndt, et al.
Publicado: (2021)

Introduction to the theory of cooperative games
por: Peleg, Bezalel, et al.
Publicado: (2007)

Proteolytic Activity of Dog Blood
por: Paly, Sidney N., et al.
Publicado: (1954)

Cannot write session to /tmp/vufind_sessions/sess_t4dess8jthe9d8fdms3brvn3sb