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Dengue virus serotypic replacement of NS3 protease or helicase domain causes chimeric viral attenuation but can be recovered by a compensated mutation at helicase domain or NS2B, respectively
Mosquito-borne dengue viruses (DENVs) have evolved to four serotypes with 69%–78% amino acid identities, resulting in incomplete immunity, where one serotype’s infection does not cross-protect against secondary infections by other serotypes. Despite the amino acid differences, structural and nonstru...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Society for Microbiology
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506484/ https://www.ncbi.nlm.nih.gov/pubmed/37555662 http://dx.doi.org/10.1128/jvi.00854-23 |