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Therapeutic Effects of Upadacitinib on Experimental Autoimmune Uveitis: Insights From Single-Cell Analysis

PURPOSE: This study aimed to elucidate the impact of upadacitinib, a Janus kinase 1 (JAK1)-specific inhibitor, on experimental autoimmune uveitis (EAU) and explore its underlying mechanisms. METHODS: We utilized single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase-accessible...

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Detalles Bibliográficos
Autores principales:	Huang, Zhaohao, Jiang, Qi, Chen, Junjie, Liu, Xiuxing, Gu, Chenyang, Tao, Tianyu, Lv, Jianjie, Li, Zhaohuai, Li, Zuohong, Su, Wenru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2023
Materias:	Immunology and Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506681/ https://www.ncbi.nlm.nih.gov/pubmed/37713206 http://dx.doi.org/10.1167/iovs.64.12.28

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