Immunobiology of a rationally-designed AAV2 capsid following intravitreal delivery in mice

Adeno-associated virus serotype 2 (AAV2) is a viral vector that can be used to deliver therapeutic genes to diseased cells in the retina. One strategy for altering AAV2 vectors involves the mutation of phosphodegron residues, which are thought to be phosphorylated/ubiquitinated in the cytosol, facil...

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Detalles Bibliográficos
Autores principales: Whitehead, Michael, Sage, Andrew, Burgoyne, Tom, Osborne, Andrew, Yu-Wai-Man, Patrick, Martin, Keith R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506909/
https://www.ncbi.nlm.nih.gov/pubmed/37386155
http://dx.doi.org/10.1038/s41434-023-00409-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506909/
https://www.ncbi.nlm.nih.gov/pubmed/37386155
http://dx.doi.org/10.1038/s41434-023-00409-x

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