Repeat or single-dose lentiviral vector administration to mouse lungs? It’s all about the timing

Lentiviral vectors are attractive delivery vehicles for cystic fibrosis gene therapy owing to their low immunogenicity and ability to integrate into the host cell genome, thereby producing long-term, stable gene expression. Nonetheless, repeat dosing may be required to increase initial expression le...

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Detalles Bibliográficos
Autores principales: Donnelley, Martin, Cmielewski, Patricia, Knight, Emma, Carpentieri, Chantelle, McCarron, Alexandra, Rout-Pitt, Nathan, Parsons, David, Farrow, Nigel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506910/
https://www.ncbi.nlm.nih.gov/pubmed/37165031
http://dx.doi.org/10.1038/s41434-023-00403-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506910/
https://www.ncbi.nlm.nih.gov/pubmed/37165031
http://dx.doi.org/10.1038/s41434-023-00403-3

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