rAAV-PHP.B escapes the mouse eye and causes lethality whereas rAAV9 can transduce aniridic corneal limbal stem cells without lethality

Recently safety concerns have been raised in connection with high doses of recombinant adeno-associated viruses (rAAV). Therefore, we undertook a series of experiments to test viral capsid (rAAV9 and rAAV-PHP.B), dose, and route of administration (intrastromal, intravitreal, and intravenous) focused...

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Detalles Bibliográficos
Autores principales: Mirjalili Mohanna, Seyedeh Zeinab, Korecki, Andrea J., Simpson, Elizabeth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506911/
https://www.ncbi.nlm.nih.gov/pubmed/37072572
http://dx.doi.org/10.1038/s41434-023-00400-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506911/
https://www.ncbi.nlm.nih.gov/pubmed/37072572
http://dx.doi.org/10.1038/s41434-023-00400-6

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