Elevated concentrations cause upright alpha-synuclein conformation at lipid interfaces

The amyloid aggregation of α-synuclein (αS), related to Parkinson’s disease, can be catalyzed by lipid membranes. Despite the importance of lipid surfaces, the 3D-structure and orientation of lipid-bound αS is still not known in detail. Here, we report interface-specific vibrational sum-frequency ge...

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Detalles Bibliográficos
Autores principales: Roeters, Steven J., Strunge, Kris, Pedersen, Kasper B., Golbek, Thaddeus W., Bregnhøj, Mikkel, Zhang, Yuge, Wang, Yin, Dong, Mingdong, Nielsen, Janni, Otzen, Daniel E., Schiøtt, Birgit, Weidner, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507035/
https://www.ncbi.nlm.nih.gov/pubmed/37723164
http://dx.doi.org/10.1038/s41467-023-39843-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507035/
https://www.ncbi.nlm.nih.gov/pubmed/37723164
http://dx.doi.org/10.1038/s41467-023-39843-1

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