Cargando…

Elevated concentrations cause upright alpha-synuclein conformation at lipid interfaces

The amyloid aggregation of α-synuclein (αS), related to Parkinson’s disease, can be catalyzed by lipid membranes. Despite the importance of lipid surfaces, the 3D-structure and orientation of lipid-bound αS is still not known in detail. Here, we report interface-specific vibrational sum-frequency ge...

Descripción completa

Detalles Bibliográficos
Autores principales:	Roeters, Steven J., Strunge, Kris, Pedersen, Kasper B., Golbek, Thaddeus W., Bregnhøj, Mikkel, Zhang, Yuge, Wang, Yin, Dong, Mingdong, Nielsen, Janni, Otzen, Daniel E., Schiøtt, Birgit, Weidner, Tobias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507035/ https://www.ncbi.nlm.nih.gov/pubmed/37723164 http://dx.doi.org/10.1038/s41467-023-39843-1

Ejemplares similares

Assembly of iron oxide nanosheets at the air–water interface by leucine–histidine peptides
por: Hoinkis, Nina, et al.
Publicado: (2021)

Ice-nucleating proteins are activated by low temperatures to control the structure of interfacial water
por: Roeters, Steven J., et al.
Publicado: (2021)

Predicting molecular properties of α‐synuclein using force fields for intrinsically disordered proteins
por: Pedersen, Kasper B., et al.
Publicado: (2022)

In-Silico Evidence for a Two Receptor Based Strategy of SARS-CoV-2
por: Milanetti, Edoardo, et al.
Publicado: (2021)

The giant staphylococcal protein Embp facilitates colonization of surfaces through Velcro-like attachment to fibrillated fibronectin
por: Khan, Nasar, et al.
Publicado: (2022)

How epigallocatechin gallate binds and assembles oligomeric forms of human alpha-synuclein
por: Andersen, Camilla B., et al.
Publicado: (2021)

A discrepancy of 10(7) in experimental and theoretical density detection limits of aerosol particles by surface nonlinear light scattering
por: Marchioro, Arianna, et al.
Publicado: (2023)

Glycation modulates alpha-synuclein fibrillization kinetics: A sweet spot for inhibition
por: Farzadfard, Azad, et al.
Publicado: (2022)

Dopamine-Induced Conformational Changes in Alpha-Synuclein
por: Outeiro, Tiago F., et al.
Publicado: (2009)

Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers
por: Alam, Parvez, et al.
Publicado: (2022)

Drug repurposing screens identify compounds that inhibit α-synuclein oligomers' membrane disruption and block antibody interactions
por: Somavarapu, Arun Kumar, et al.
Publicado: (2023)

Dimer Interface of the Human Serotonin Transporter and Effect of the Membrane Composition
por: Periole, Xavier, et al.
Publicado: (2018)

Two conformationally distinct α-synuclein oligomers share common epitopes and the ability to impair long-term potentiation
por: van Diggelen, Femke, et al.
Publicado: (2019)

Binding of Dopamine to Alpha-Synuclein is Mediated by Specific Conformational States
por: Illes-Toth, Eva, et al.
Publicado: (2013)

Reducing the Amyloidogenicity of Functional Amyloid Protein FapC Increases Its Ability To Inhibit α-Synuclein Fibrillation
por: Christensen, Line Friis Bakmann, et al.
Publicado: (2019)

Alpha-Synuclein—Nanoparticle Interactions: Understanding, Controlling and Exploiting Conformational Plasticity
por: D’Onofrio, Mariapina, et al.
Publicado: (2020)

Ligand Induced Conformational Changes of the Human Serotonin Transporter Revealed by Molecular Dynamics Simulations
por: Koldsø, Heidi, et al.
Publicado: (2013)

Synthetic Artificial Apoptosis‐Inducing Receptor for On‐Demand Deactivation of Engineered Cells
por: Monge, Pere, et al.
Publicado: (2021)

Low dose DMSO treatment induces oligomerization and accelerates aggregation of α-synuclein
por: Reimer, Lasse, et al.
Publicado: (2022)

Upright digital stereotaxis
por: Evans, A
Publicado: (2000)

Disadvantages of the Upright Position
por: Clevenger, S. V.
Publicado: (1884)

Effect of palmitoylation on the dimer formation of the human dopamine transporter
por: Zeppelin, Talia, et al.
Publicado: (2021)

The Effect of Cholesterol on Membrane-Bound Islet Amyloid Polypeptide
por: Christensen, Mikkel, et al.
Publicado: (2021)

Rapid restructurization of conformationally-distinct alpha-synuclein amyloid fibrils at an elevated temperature
por: Ziaunys, Mantas, et al.
Publicado: (2022)

A penetratin-derived peptide reduces the membrane permeabilization and cell toxicity of α-synuclein oligomers
por: Pirhaghi, Mitra, et al.
Publicado: (2022)

Upright Imaging of Drosophila Embryos
por: Belu, Mirela, et al.
Publicado: (2010)

The Begg's uprighting spring – Revisited
por: Kumar, Vinay, et al.
Publicado: (2015)

Anatomical Constellations for Upright Hypoxemia
por: Yastrebov, Konstantin, et al.
Publicado: (2022)

Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization
por: Sahin, Cagla, et al.
Publicado: (2022)

Crowding of Upright Chinese Character is Stronger with Inverted than Upright Flankers: An Exception of the Similarity Rule
por: Lau, Siu-Fung, et al.
Publicado: (2011)

Unbiased Simulations Reveal the Inward-Facing Conformation of the Human Serotonin Transporter and Na(+) Ion Release
por: Koldsø, Heidi, et al.
Publicado: (2011)

The Bacterial Amyloids Phenol Soluble Modulins from Staphylococcus aureus Catalyze Alpha-Synuclein Aggregation
por: Haikal, Caroline, et al.
Publicado: (2021)

Anatomical cardiac and electrocardiographic axes correlate in both upright and supine positions: an upright/supine CT study
por: Norimatsu, Togo, et al.
Publicado: (2023)

Small Molecules Attenuate the Interplay between Conformational Fluctuations, Early Oligomerization and Amyloidosis of Alpha Synuclein
por: Ghosh, Sumanta, et al.
Publicado: (2018)

Navigating the dynamic landscape of alpha-synuclein morphology: a review of the physiologically relevant tetrameric conformation
por: Lucas, Heather R., et al.
Publicado: (2019)

Development and Decline of Upright Gait Stability
por: Iosa, Marco, et al.
Publicado: (2014)

Neutral buoyancy and the static perception of upright
por: Jenkin, Heather, et al.
Publicado: (2023)

Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein
por: Dening, Yanina, et al.
Publicado: (2022)

Evidence for Intramolecular Antiparallel Beta-Sheet Structure in Alpha-Synuclein Fibrils from a Combination of Two-Dimensional Infrared Spectroscopy and Atomic Force Microscopy
por: Roeters, Steven J., et al.
Publicado: (2017)

Anatomical changes in the male pelvis between the supine and upright positions—A feasibility study for prostate treatments in the upright position
por: Schreuder, Andries (Niek), et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_j79ipdgmpd3b2tsl1l09csk2jn