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Discovery of the major 15–30 nt mammalian small RNAs, their biogenesis and function

Small RNAs (sRNAs) within 15-30 nt such as miRNA, tsRNA, srRNA with 3’-OH have been identified. However, whether these sRNAs are the major 15-30 nt sRNAs is still unknown. Here we show about 90% mammalian sRNAs within 15-30 nt end with 2’,3’-cyclic phosphate (3’-cP). TANT-seq was developed to simult...

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Detalles Bibliográficos
Autores principales: Lai, Hejin, Feng, Ning, Zhai, Qiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507107/
https://www.ncbi.nlm.nih.gov/pubmed/37723159
http://dx.doi.org/10.1038/s41467-023-41554-6