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Deficiency in AK9 causes asthenozoospermia and male infertility by destabilising sperm nucleotide homeostasis

BACKGROUND: Asthenozoospermia is the primary cause of male infertility; however, its genetic aetiology remains poorly understood. Adenylate kinase 9 (AK9) is highly expressed in the testes of humans and mice and encodes a type of adenosine kinase that is functionally involved in cellular nucleotide...

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Detalles Bibliográficos
Autores principales: Sha, Yanwei, Liu, Wensheng, Li, Shu, Osadchuk, Ludmila V., Chen, Yongjie, Nie, Hua, Gao, Shuai, Xie, Linna, Qin, Weibing, Zhou, Huiliang, Li, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507140/
https://www.ncbi.nlm.nih.gov/pubmed/37713809
http://dx.doi.org/10.1016/j.ebiom.2023.104798