N4-hydroxycytidine, the active compound of Molnupiravir, promotes SARS-CoV-2 mutagenesis and escape from a neutralizing nanobody

N4-hydroxycytidine (NHC), the active compound of the drug Molnupiravir, is incorporated into SARS-CoV-2 RNA, causing false base pairing. The desired result is an “error catastrophe,” but this bears the risk of mutated virus progeny. To address this experimentally, we propagated the initial SARS-CoV-...

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Detalles Bibliográficos
Autores principales: Zibat, Arne, Zhang, Xiaoxiao, Dickmanns, Antje, Stegmann, Kim M., Dobbelstein, Adrian W., Alachram, Halima, Soliwoda, Rebecca, Salinas, Gabriela, Groß, Uwe, Görlich, Dirk, Kschischo, Maik, Wollnik, Bernd, Dobbelstein, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507161/
https://www.ncbi.nlm.nih.gov/pubmed/37731621
http://dx.doi.org/10.1016/j.isci.2023.107786

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507161/
https://www.ncbi.nlm.nih.gov/pubmed/37731621
http://dx.doi.org/10.1016/j.isci.2023.107786

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