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Research progress on extracellular vesicles in the renal tubular injury of diabetic kidney disease

Diabetic kidney disease (DKD) is a severe microvascular complication of diabetes and is a chronic progressive condition. It is also a common cause of end-stage renal disease (ESRD), which is characterized by proteinuria or a progressive decline in the glomerular filtration rate. Due to their depende...

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Autores principales: Li, Shengjie, Zheng, Shanshan, Li, Jiao, Lin, Sen, Li, Hao, Wang, Ping, Chen, Ping, Ma, Chaoqun, Liu, Yipeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507342/
https://www.ncbi.nlm.nih.gov/pubmed/37732129
http://dx.doi.org/10.3389/fendo.2023.1257430
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author Li, Shengjie
Zheng, Shanshan
Li, Jiao
Lin, Sen
Li, Hao
Wang, Ping
Chen, Ping
Ma, Chaoqun
Liu, Yipeng
author_facet Li, Shengjie
Zheng, Shanshan
Li, Jiao
Lin, Sen
Li, Hao
Wang, Ping
Chen, Ping
Ma, Chaoqun
Liu, Yipeng
author_sort Li, Shengjie
collection PubMed
description Diabetic kidney disease (DKD) is a severe microvascular complication of diabetes and is a chronic progressive condition. It is also a common cause of end-stage renal disease (ESRD), which is characterized by proteinuria or a progressive decline in the glomerular filtration rate. Due to their dependence on high-energy and aerobic metabolism, renal tubules are more susceptible to the metabolic disturbances associated with DKD, leading to inflammation and fibrosis. Consequently, tubular injury has become a recent research focus, and significant advancements have been made in studying the role of extracellular vesicles in DKD-associated tubular injury. This review aimed to elucidate the mechanisms and potential applications of different types of extracellular vesicles in tubular injury in DKD to provide new insights for the prevention and treatment of DKD.
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spelling pubmed-105073422023-09-20 Research progress on extracellular vesicles in the renal tubular injury of diabetic kidney disease Li, Shengjie Zheng, Shanshan Li, Jiao Lin, Sen Li, Hao Wang, Ping Chen, Ping Ma, Chaoqun Liu, Yipeng Front Endocrinol (Lausanne) Endocrinology Diabetic kidney disease (DKD) is a severe microvascular complication of diabetes and is a chronic progressive condition. It is also a common cause of end-stage renal disease (ESRD), which is characterized by proteinuria or a progressive decline in the glomerular filtration rate. Due to their dependence on high-energy and aerobic metabolism, renal tubules are more susceptible to the metabolic disturbances associated with DKD, leading to inflammation and fibrosis. Consequently, tubular injury has become a recent research focus, and significant advancements have been made in studying the role of extracellular vesicles in DKD-associated tubular injury. This review aimed to elucidate the mechanisms and potential applications of different types of extracellular vesicles in tubular injury in DKD to provide new insights for the prevention and treatment of DKD. Frontiers Media S.A. 2023-09-04 /pmc/articles/PMC10507342/ /pubmed/37732129 http://dx.doi.org/10.3389/fendo.2023.1257430 Text en Copyright © 2023 Li, Zheng, Li, Lin, Li, Wang, Chen, Ma and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Li, Shengjie
Zheng, Shanshan
Li, Jiao
Lin, Sen
Li, Hao
Wang, Ping
Chen, Ping
Ma, Chaoqun
Liu, Yipeng
Research progress on extracellular vesicles in the renal tubular injury of diabetic kidney disease
title Research progress on extracellular vesicles in the renal tubular injury of diabetic kidney disease
title_full Research progress on extracellular vesicles in the renal tubular injury of diabetic kidney disease
title_fullStr Research progress on extracellular vesicles in the renal tubular injury of diabetic kidney disease
title_full_unstemmed Research progress on extracellular vesicles in the renal tubular injury of diabetic kidney disease
title_short Research progress on extracellular vesicles in the renal tubular injury of diabetic kidney disease
title_sort research progress on extracellular vesicles in the renal tubular injury of diabetic kidney disease
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507342/
https://www.ncbi.nlm.nih.gov/pubmed/37732129
http://dx.doi.org/10.3389/fendo.2023.1257430
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