Trifluoromethylthiolation of Tryptophan and Tyrosine Derivatives: A Tool for Enhancing the Local Hydrophobicity of Peptides

[Image: see text] The incorporation of fluorinated groups into peptides significantly affects their biophysical properties. We report herein the synthesis of Fmoc-protected trifluoromethylthiolated tyrosine (CF(3)S-Tyr) and tryptophan (CF(3)S-Trp) analogues on a gram scale (77–93% yield) and demonst...

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Detalles Bibliográficos
Autores principales: Gregorc, Jure, Lensen, Nathalie, Chaume, Grégory, Iskra, Jernej, Brigaud, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507666/
https://www.ncbi.nlm.nih.gov/pubmed/37672679
http://dx.doi.org/10.1021/acs.joc.3c01373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507666/
https://www.ncbi.nlm.nih.gov/pubmed/37672679
http://dx.doi.org/10.1021/acs.joc.3c01373

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