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Trifluoromethylthiolation of Tryptophan and Tyrosine Derivatives: A Tool for Enhancing the Local Hydrophobicity of Peptides
[Image: see text] The incorporation of fluorinated groups into peptides significantly affects their biophysical properties. We report herein the synthesis of Fmoc-protected trifluoromethylthiolated tyrosine (CF(3)S-Tyr) and tryptophan (CF(3)S-Trp) analogues on a gram scale (77–93% yield) and demonst...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507666/ https://www.ncbi.nlm.nih.gov/pubmed/37672679 http://dx.doi.org/10.1021/acs.joc.3c01373 |