En route to local glioblastoma treatment with temozolomide doped hyaluronan fibres: formulation and in vitro cell studies

We report the preparation, characterisation and in vitro tests of hyaluronan fibres containing up to 50 w/w% of temozolomide for local glyoblastoma treatment. These fibres form a hydrogel upon contact with cerebrospinal fluid on the treatment spot.

Detalles Bibliográficos
Autores principales: Belhajová, Marie, Vícha, Aleš, Burgert, Ladislav, Brožková, Iveta, Michalíčková, Ludmila, Hrdina, Radim, Moravec, Tomáš, Netuka, David, Musil, Zdeněk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507811/
https://www.ncbi.nlm.nih.gov/pubmed/37731694
http://dx.doi.org/10.1039/d3md00261f
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author Belhajová, Marie
Vícha, Aleš
Burgert, Ladislav
Brožková, Iveta
Michalíčková, Ludmila
Hrdina, Radim
Moravec, Tomáš
Netuka, David
Musil, Zdeněk
Hrdina, Radim
author_facet Belhajová, Marie
Vícha, Aleš
Burgert, Ladislav
Brožková, Iveta
Michalíčková, Ludmila
Hrdina, Radim
Moravec, Tomáš
Netuka, David
Musil, Zdeněk
Hrdina, Radim
author_sort Belhajová, Marie
collection PubMed
description We report the preparation, characterisation and in vitro tests of hyaluronan fibres containing up to 50 w/w% of temozolomide for local glyoblastoma treatment. These fibres form a hydrogel upon contact with cerebrospinal fluid on the treatment spot.
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spelling pubmed-105078112023-09-20 En route to local glioblastoma treatment with temozolomide doped hyaluronan fibres: formulation and in vitro cell studies Belhajová, Marie Vícha, Aleš Burgert, Ladislav Brožková, Iveta Michalíčková, Ludmila Hrdina, Radim Moravec, Tomáš Netuka, David Musil, Zdeněk Hrdina, Radim RSC Med Chem Chemistry We report the preparation, characterisation and in vitro tests of hyaluronan fibres containing up to 50 w/w% of temozolomide for local glyoblastoma treatment. These fibres form a hydrogel upon contact with cerebrospinal fluid on the treatment spot. RSC 2023-08-03 /pmc/articles/PMC10507811/ /pubmed/37731694 http://dx.doi.org/10.1039/d3md00261f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Belhajová, Marie
Vícha, Aleš
Burgert, Ladislav
Brožková, Iveta
Michalíčková, Ludmila
Hrdina, Radim
Moravec, Tomáš
Netuka, David
Musil, Zdeněk
Hrdina, Radim
En route to local glioblastoma treatment with temozolomide doped hyaluronan fibres: formulation and in vitro cell studies
title En route to local glioblastoma treatment with temozolomide doped hyaluronan fibres: formulation and in vitro cell studies
title_full En route to local glioblastoma treatment with temozolomide doped hyaluronan fibres: formulation and in vitro cell studies
title_fullStr En route to local glioblastoma treatment with temozolomide doped hyaluronan fibres: formulation and in vitro cell studies
title_full_unstemmed En route to local glioblastoma treatment with temozolomide doped hyaluronan fibres: formulation and in vitro cell studies
title_short En route to local glioblastoma treatment with temozolomide doped hyaluronan fibres: formulation and in vitro cell studies
title_sort en route to local glioblastoma treatment with temozolomide doped hyaluronan fibres: formulation and in vitro cell studies
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507811/
https://www.ncbi.nlm.nih.gov/pubmed/37731694
http://dx.doi.org/10.1039/d3md00261f
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