Promiscuous splicing-derived hairpins are dominant substrates of tailing-mediated defense of miRNA biogenesis in mammals

Canonical microRNA (miRNA) hairpins are processed by the RNase III enzymes Drosha and Dicer into ~22 nt RNAs loaded into an Argonaute (Ago) effector. In addition, splicing generates numerous intronic hairpins that bypass Drosha (mirtrons) to yield mature miRNAs. Here, we identify hundreds of previou...

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Detalles Bibliográficos
Autores principales: Lee, Seungjae, Jee, David, Srivastava, Sid, Yang, Acong, Ramidi, Abhinav, Shang, Renfu, Bortolamiol-Becet, Diane, Pfeffer, Sébastien, Gu, Shuo, Wen, Jiayu, Lai, Eric C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508058/
https://www.ncbi.nlm.nih.gov/pubmed/36800291
http://dx.doi.org/10.1016/j.celrep.2023.112111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508058/
https://www.ncbi.nlm.nih.gov/pubmed/36800291
http://dx.doi.org/10.1016/j.celrep.2023.112111

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