ADP-ribosylation-resistant rifabutin analogs show improved bactericidal activity against drug-tolerant M. abscessus in caseum surrogate

Necrotic lesions and cavities filled with caseum are a hallmark of mycobacterial pulmonary disease. Bronchocavitary Mycobacterium abscessus disease is associated with poor treatment outcomes. In caseum surrogate, M. abscessus entered an extended stationary phase showing tolerance to killing by most...

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Autores principales: Xie, Min, Ganapathy, Uday S., Lan, Tian, Osiecki, Paulina, Sarathy, Jansy P., Dartois, Véronique, Aldrich, Courtney C., Dick, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508146/
https://www.ncbi.nlm.nih.gov/pubmed/37493373
http://dx.doi.org/10.1128/aac.00381-23
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author Xie, Min
Ganapathy, Uday S.
Lan, Tian
Osiecki, Paulina
Sarathy, Jansy P.
Dartois, Véronique
Aldrich, Courtney C.
Dick, Thomas
author_facet Xie, Min
Ganapathy, Uday S.
Lan, Tian
Osiecki, Paulina
Sarathy, Jansy P.
Dartois, Véronique
Aldrich, Courtney C.
Dick, Thomas
author_sort Xie, Min
collection PubMed
description Necrotic lesions and cavities filled with caseum are a hallmark of mycobacterial pulmonary disease. Bronchocavitary Mycobacterium abscessus disease is associated with poor treatment outcomes. In caseum surrogate, M. abscessus entered an extended stationary phase showing tolerance to killing by most current antibiotics, suggesting that caseum persisters contribute to the poor performance of available treatments. Novel ADP-ribosylation-resistant rifabutin analogs exhibited bactericidal activity against these M. abscessus persisters at concentrations achievable by rifamycins in caseum.
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spelling pubmed-105081462023-09-20 ADP-ribosylation-resistant rifabutin analogs show improved bactericidal activity against drug-tolerant M. abscessus in caseum surrogate Xie, Min Ganapathy, Uday S. Lan, Tian Osiecki, Paulina Sarathy, Jansy P. Dartois, Véronique Aldrich, Courtney C. Dick, Thomas Antimicrob Agents Chemother Experimental Therapeutics Necrotic lesions and cavities filled with caseum are a hallmark of mycobacterial pulmonary disease. Bronchocavitary Mycobacterium abscessus disease is associated with poor treatment outcomes. In caseum surrogate, M. abscessus entered an extended stationary phase showing tolerance to killing by most current antibiotics, suggesting that caseum persisters contribute to the poor performance of available treatments. Novel ADP-ribosylation-resistant rifabutin analogs exhibited bactericidal activity against these M. abscessus persisters at concentrations achievable by rifamycins in caseum. American Society for Microbiology 2023-07-26 /pmc/articles/PMC10508146/ /pubmed/37493373 http://dx.doi.org/10.1128/aac.00381-23 Text en Copyright © 2023 Xie et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Experimental Therapeutics
Xie, Min
Ganapathy, Uday S.
Lan, Tian
Osiecki, Paulina
Sarathy, Jansy P.
Dartois, Véronique
Aldrich, Courtney C.
Dick, Thomas
ADP-ribosylation-resistant rifabutin analogs show improved bactericidal activity against drug-tolerant M. abscessus in caseum surrogate
title ADP-ribosylation-resistant rifabutin analogs show improved bactericidal activity against drug-tolerant M. abscessus in caseum surrogate
title_full ADP-ribosylation-resistant rifabutin analogs show improved bactericidal activity against drug-tolerant M. abscessus in caseum surrogate
title_fullStr ADP-ribosylation-resistant rifabutin analogs show improved bactericidal activity against drug-tolerant M. abscessus in caseum surrogate
title_full_unstemmed ADP-ribosylation-resistant rifabutin analogs show improved bactericidal activity against drug-tolerant M. abscessus in caseum surrogate
title_short ADP-ribosylation-resistant rifabutin analogs show improved bactericidal activity against drug-tolerant M. abscessus in caseum surrogate
title_sort adp-ribosylation-resistant rifabutin analogs show improved bactericidal activity against drug-tolerant m. abscessus in caseum surrogate
topic Experimental Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508146/
https://www.ncbi.nlm.nih.gov/pubmed/37493373
http://dx.doi.org/10.1128/aac.00381-23
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