Cargando…
Lung microenvironments harbor Mycobacterium tuberculosis phenotypes with distinct treatment responses
Tuberculosis lung lesions are complex and harbor heterogeneous microenvironments that influence antibiotic effectiveness. Major strides have been made recently in understanding drug pharmacokinetics in pulmonary lesions, but the bacterial phenotypes that arise under these conditions and their contri...
Autores principales: | Walter, Nicholas D., Ernest, Jackie P., Dide-Agossou, Christian, Bauman, Allison A., Ramey, Michelle E., Rossmassler, Karen, Massoudi, Lisa M., Pauly, Samantha, Al Mubarak, Reem, Voskuil, Martin I., Kaya, Firat, Sarathy, Jansy P., Zimmerman, Matthew D., Dartois, Véronique, Podell, Brendan K., Savic, Radojka M., Robertson, Gregory T. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508168/ https://www.ncbi.nlm.nih.gov/pubmed/37565762 http://dx.doi.org/10.1128/aac.00284-23 |
Ejemplares similares
-
Drug distribution and efficacy of the DprE1 inhibitor BTZ-043 in the C3HeB/FeJ mouse tuberculosis model
por: Ramey, Michelle E., et al.
Publicado: (2023) -
Combination of Mycobacterium tuberculosis RS Ratio and CFU Improves the Ability of Murine Efficacy Experiments to Distinguish between Drug Treatments
por: Dide-Agossou, Christian, et al.
Publicado: (2022) -
ADP-ribosylation-resistant rifabutin analogs show improved bactericidal activity against drug-tolerant M. abscessus in caseum surrogate
por: Xie, Min, et al.
Publicado: (2023) -
On-Slide Heat Sterilization Enables Mass Spectrometry
Imaging of Tissue Infected with High-Threat Pathogens Outside of Biocontainment:
A Study Directed at Mycobacterium tuberculosis
por: Wang, Ning, et al.
Publicado: (2021) -
Lesion Penetration and Activity Limit the Utility of Second-Line Injectable Agents in Pulmonary Tuberculosis
por: Ernest, Jacqueline P., et al.
Publicado: (2021)