Development and application of a PBPK modeling strategy to support antimalarial drug development

As part of a collaboration between Medicines for Malaria Venture (MMV), Certara UK and Monash University, physiologically‐based pharmacokinetic (PBPK) models were developed for 20 antimalarials, using data obtained from standardized in vitro assays and clinical studies within the literature. The mod...

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Detalles Bibliográficos
Autores principales: Abla, Nada, Howgate, Eleanor, Rowland‐Yeo, Karen, Dickins, Maurice, Bergagnini‐Kolev, Mackenzie C., Chen, Kuan‐Fu, McFeely, Savannah, Bonner, Jennifer J., Santos, Laura G. A., Gobeau, Nathalie, Burt, Howard, Barter, Zoe, Jones, Hannah M., Wesche, David, Charman, Susan A., Möhrle, Jörg J., Burrows, Jeremy N., Almond, Lisa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508484/
https://www.ncbi.nlm.nih.gov/pubmed/37587640
http://dx.doi.org/10.1002/psp4.13013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508484/
https://www.ncbi.nlm.nih.gov/pubmed/37587640
http://dx.doi.org/10.1002/psp4.13013

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