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The selective D3-Receptor antagonist VK4-116 effectively treats behavioral inflexibility in rats caused by self-administration and withdrawal from cocaine

Chronic psychostimulant use can cause long lasting changes to neural and cognitive function that persist even after long periods of abstinence. As cocaine users transition from drug use to abstinence, a parallel transition from hyperactivity to hypoactivity has been found in orbitofrontal-striatal g...

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Detalles Bibliográficos
Autores principales: Panayi, Marios C., Shetty, Shohan, Porod, Micaela, Bahena, Lisette, Xi, Zheng-Xiong, Newman, Amy Hauck, Schoenbaum, Geoffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508727/
https://www.ncbi.nlm.nih.gov/pubmed/37732238
http://dx.doi.org/10.1101/2023.09.03.556083