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Host cell glycosylation selects for infection with CCR5- versus CXCR4-tropic HIV-1

HIV-1 infection involves a selection bottleneck that leads to transmission of one or a few HIV variants, which nearly always use CCR5 as the coreceptor (R5 viruses) for viral entry as opposed to CXCR4 (X4 viruses). The host properties that drive this selection are not well understood and may hold ke...

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Detalles Bibliográficos
Autores principales: Itell, Hannah L., Humes, Daryl, Baumgarten, Nell E., Overbaugh, Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508750/
https://www.ncbi.nlm.nih.gov/pubmed/37732222
http://dx.doi.org/10.1101/2023.09.05.556399