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Loss of ATP-sensitive channel expression and function decreases opioid sensitivity in a mouse model of type 2 diabetes
During diabetes, β-cell dysfunction due to loss of potassium channels sensitive to ATP, known as K(ATP) channels occurs progressively over time contributing to hyperglycemia. K(ATP) channels are additionally present in the central and peripheral nervous systems and are downstream targets of opioid r...
Autores principales: | Fisher, Cole, Johnson, Kayla, Moore, Madelyn, Sadrati, Amir, Janecek, Jody L., Graham, Melanie L., Klein, Amanda H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508758/ https://www.ncbi.nlm.nih.gov/pubmed/37732180 http://dx.doi.org/10.1101/2023.09.06.556526 |
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