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Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need
Addiction prioritizes drug use over innate needs by “hijacking” brain circuits that direct motivation, but how this develops remains unclear. Using whole-brain FOS mapping and in vivo single-neuron calcium imaging, we find that drugs of abuse augment ensemble activity in the nucleus accumbens (NAc)...
Autores principales: | Tan, Bowen, Browne, Caleb J., Nöbauer, Tobias, Vaziri, Alipasha, Friedman, Jeffrey M., Nestler, Eric J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508763/ https://www.ncbi.nlm.nih.gov/pubmed/37732251 http://dx.doi.org/10.1101/2023.09.03.556059 |
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