Structural Mechanisms for VMAT2 inhibition by tetrabenazine

The vesicular monoamine transporter 2 (VMAT2) is a proton-dependent antiporter responsible for loading monoamine neurotransmitters into synaptic vesicles. Dysregulation of VMAT2 can lead to several neuropsychiatric disorders including Parkinson’s disease and schizophrenia. Furthermore, drugs such as...

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Detalles Bibliográficos
Autores principales: Dalton, Michael P., Cheng, Mary Hongying, Bahar, Ivet, Coleman, Jonathan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508774/
https://www.ncbi.nlm.nih.gov/pubmed/37732203
http://dx.doi.org/10.1101/2023.09.05.556211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508774/
https://www.ncbi.nlm.nih.gov/pubmed/37732203
http://dx.doi.org/10.1101/2023.09.05.556211

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