Cargando…

Structural Mechanisms for VMAT2 inhibition by tetrabenazine

The vesicular monoamine transporter 2 (VMAT2) is a proton-dependent antiporter responsible for loading monoamine neurotransmitters into synaptic vesicles. Dysregulation of VMAT2 can lead to several neuropsychiatric disorders including Parkinson’s disease and schizophrenia. Furthermore, drugs such as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dalton, Michael P., Cheng, Mary Hongying, Bahar, Ivet, Coleman, Jonathan A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508774/ https://www.ncbi.nlm.nih.gov/pubmed/37732203 http://dx.doi.org/10.1101/2023.09.05.556211

Ejemplares similares

The VMAT-2 Inhibitor Tetrabenazine Affects Effort-Related Decision Making in a Progressive Ratio/Chow Feeding Choice Task: Reversal with Antidepressant Drugs
por: Randall, Patrick A., et al.
Publicado: (2014)

Tetrabenazine in the treatment of Huntington’s disease
por: Paleacu, Diana
Publicado: (2007)

Tetrabenazine is neuroprotective in Huntington's disease mice
por: Wang, Hongyu, et al.
Publicado: (2010)

Management of Huntington’s disease: role of tetrabenazine
por: de Tommaso, Marina, et al.
Publicado: (2011)

Shared dynamics of LeuT superfamily members and allosteric differentiation by structural irregularities and multimerization
por: Ponzoni, Luca, et al.
Publicado: (2018)

Complete Mapping of Substrate Translocation Highlights the Role of LeuT N-terminal Segment in Regulating Transport Cycle
por: Cheng, Mary Hongying, et al.
Publicado: (2014)

Behaviour of Tetrabenazine in Acid Medium: Reassessment and Impact on Formulation
por: Ettouati, Laurent, et al.
Publicado: (2019)

Pharmacokinetics of Deutetrabenazine and Tetrabenazine: Dose Proportionality and Food Effect
por: Schneider, Frank, et al.
Publicado: (2020)

Indirect tolerability comparison of Deutetrabenazine and Tetrabenazine for Huntington disease
por: Claassen, Daniel O., et al.
Publicado: (2017)

Treatment of Tardive Dyskinesia by tetrabenazine, clonazepam and vitamin E
por: Sharma, Himanshu
Publicado: (2009)

Dual Treatment of Hemichorea–Hemiballismus Syndrome with Tetrabenazine and Chemodenervation
por: Umeh, Chizoba C., et al.
Publicado: (2012)

Effect of Tetrabenazine on Motor Function in Patients with Huntington Disease
por: Ferrara, Joseph M., et al.
Publicado: (2012)

Synthesis of Tetrabenazine and Its Derivatives, Pursuing Efficiency and Selectivity
por: Paek, Seung-Mann
Publicado: (2020)

Tetrabenazine Versus Deutetrabenazine for Huntington's Disease: Twins or Distant Cousins?
por: Rodrigues, Filipe B., et al.
Publicado: (2017)

Differences in Dihydrotetrabenazine Isomer Concentrations Following Administration of Tetrabenazine and Valbenazine
por: Skor, Heather, et al.
Publicado: (2017)

Unique Case Reports of Tooth Sensitivity After Consuming Tetrabenazine
por: Daripa, Bob
Publicado: (2022)

An insertion unique to SARS-CoV-2 exhibits superantigenic character strengthened by recent mutations
por: Cheng, Mary Hongying, et al.
Publicado: (2020)

Effect of Dimerization on the Dynamics of Neurotransmitter:Sodium Symporters
por: Gur, Mert, et al.
Publicado: (2017)

Quadriparesis and dysarthria due to tetrabenazine therapy in a child with rheumatic chorea
por: Zaki, Syed Ahmed, et al.
Publicado: (2011)

Enantioselective synthesis of (−)-tetrabenazine via continuous crystallization-induced diastereomer transformation
por: Kukor, Andrew J., et al.
Publicado: (2022)

Multisystem Inflammatory Syndrome in Children and Long COVID: The SARS-CoV-2 Viral Superantigen Hypothesis
por: Noval Rivas, Magali, et al.
Publicado: (2022)

Pharmacokinetic and Metabolic Profile of Deutetrabenazine (TEV‐50717) Compared With Tetrabenazine in Healthy Volunteers
por: Schneider, Frank, et al.
Publicado: (2020)

Direct coupling of oligomerization and oligomerization-driven endocytosis of the dopamine transporter to its conformational mechanics and activity
por: Sorkina, Tatiana, et al.
Publicado: (2021)

Effective treatment of choreaballism due to an MT‐CYB variant with haloperidol, tetrabenazine, and antioxidants
por: Finsterer, Josef, et al.
Publicado: (2023)

Tetrabenazine: the first approved drug for the treatment of chorea in US patients with Huntington disease
por: Frank, Samuel
Publicado: (2010)

A case of tics presenting as chronic intractable cough successfully treated with tetrabenazine
por: Pawar, Deepak G., et al.
Publicado: (2015)

Tardive Dyskinesia After Aripiprazole Treatment That Improved With Tetrabenazine, Clozapine, and Botulinum Toxin
por: Aguilar, Lourdes, et al.
Publicado: (2019)

Functional Characterization of the Dopaminergic Psychostimulant Sydnocarb as an Allosteric Modulator of the Human Dopamine Transporter
por: Aggarwal, Shaili, et al.
Publicado: (2021)

Correction:Tetrabenazine as anti-chorea therapy in Huntington Disease: an open-label continuation study
por: Frank, Samuel
Publicado: (2011)

COVID-19–associated multisystem inflammatory syndrome in children (MIS-C): A novel disease that mimics toxic shock syndrome—the superantigen hypothesis
por: Noval Rivas, Magali, et al.
Publicado: (2021)

Exploring the Conformational Transitions of Biomolecular Systems Using a Simple Two-State Anisotropic Network Model
por: Das, Avisek, et al.
Publicado: (2014)

The Gene Polymorphism of VMAT2 Is Associated with Risk of Schizophrenia in Male Han Chinese
por: Han, Hongying, et al.
Publicado: (2020)

Preference for Exercise vs. More Sedentary Reinforcers: Validation of an Animal Model of Tetrabenazine-Induced Anergia
por: Carratalá-Ros, Carla, et al.
Publicado: (2020)

A Retrospective Longitudinal Study in a Cohort of Children With Dyskinetic Cerebral Palsy Treated With Tetrabenazine
por: Scalise, Roberta, et al.
Publicado: (2021)

A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro
por: Cheng, Mary Hongying, et al.
Publicado: (2020)

A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro
por: Cheng, Mary Hongying, et al.
Publicado: (2021)

Sequence Evolution Correlates with Structural Dynamics
por: Liu, Ying, et al.
Publicado: (2012)

Insights into the Modulation of Dopamine Transporter Function by Amphetamine, Orphenadrine, and Cocaine Binding
por: Cheng, Mary Hongying, et al.
Publicado: (2015)

Impact of new variants on SARS-CoV-2 infectivity and neutralization: A molecular assessment of the alterations in the spike-host protein interactions
por: Cheng, Mary Hongying, et al.
Publicado: (2022)

Structural Dynamics Predominantly Determine the Adaptability of Proteins to Amino Acid Deletions
por: Banerjee, Anupam, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ai9qfukrojdm2g7a49p98rbkeu