Using a polygenic score to account for genomic risk factors in a model to detect individuals with dilated ascending thoracic aortas

BACKGROUND: Ascending thoracic aortic dilation is a complex trait that involves modifiable and non-modifiable risk factors and can lead to thoracic aortic aneurysm and dissection. Clinical risk factors have been shown to predict ascending thoracic aortic diameter. Polygenic scores (PGS) are increasi...

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Detalles Bibliográficos
Autores principales: DePaolo, John, Biagetti, Gina, Judy, Renae, Wang, Grace J., Kelly, John, Iyengar, Amit, Goel, Nicholas J., Desai, Nimesh, Szeto, Wilson Y., Bavaria, Joseph E., Levin, Michael G., Damrauer, Scott M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508815/
https://www.ncbi.nlm.nih.gov/pubmed/37732226
http://dx.doi.org/10.1101/2023.09.06.23295145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508815/
https://www.ncbi.nlm.nih.gov/pubmed/37732226
http://dx.doi.org/10.1101/2023.09.06.23295145

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