Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification

CRISPR base editing screens are powerful tools for studying disease-associated variants at scale. However, the efficiency and precision of base editing perturbations vary, confounding the assessment of variant-induced phenotypic effects. Here, we provide an integrated pipeline that improves the esti...

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Detalles Bibliográficos
Autores principales: Ryu, Jayoung, Barkal, Sam, Yu, Tian, Jankowiak, Martin, Zhou, Yunzhuo, Francoeur, Matthew, Phan, Quang Vinh, Li, Zhijian, Tognon, Manuel, Brown, Lara, Love, Michael I., Lettre, Guillaume, Ascher, David B., Cassa, Christopher A., Sherwood, Richard I., Pinello, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508837/
https://www.ncbi.nlm.nih.gov/pubmed/37732177
http://dx.doi.org/10.1101/2023.09.08.23295253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508837/
https://www.ncbi.nlm.nih.gov/pubmed/37732177
http://dx.doi.org/10.1101/2023.09.08.23295253

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