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Nucleotide-free structures of KIF20A illuminate atypical mechanochemistry in this kinesin-6
KIF20A is a critical kinesin for cell division and a promising anti-cancer drug target. The mechanisms underlying its cellular roles remain elusive. Interestingly, unusual coupling between the nucleotide- and microtubule-binding sites of this kinesin-6 has been reported, but little is known about ho...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508983/ https://www.ncbi.nlm.nih.gov/pubmed/37726093 http://dx.doi.org/10.1098/rsob.230122 |