Nucleotide-free structures of KIF20A illuminate atypical mechanochemistry in this kinesin-6

KIF20A is a critical kinesin for cell division and a promising anti-cancer drug target. The mechanisms underlying its cellular roles remain elusive. Interestingly, unusual coupling between the nucleotide- and microtubule-binding sites of this kinesin-6 has been reported, but little is known about ho...

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Detalles Bibliográficos
Autores principales: Ranaivoson, Fanomezana Moutse, Crozet, Vincent, Benoit, Matthieu P. M. H., Abdalla Mohammed Khalid, Amna, Kikuti, Carlos, Sirkia, Helena, El Marjou, Ahmed, Miserey-Lenkei, Stéphanie, Asenjo, Ana B., Sosa, Hernando, Schmidt, Christoph F., Rosenfeld, Steven S., Houdusse, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508983/
https://www.ncbi.nlm.nih.gov/pubmed/37726093
http://dx.doi.org/10.1098/rsob.230122

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