A 3D adrenocortical carcinoma tumor platform for preclinical modeling of drug response and matrix metalloproteinase activity

Adrenocortical carcinoma (ACC) has a poor prognosis, and no new drugs have been identified in decades. The absence of drug development can partly be attributed to a lack of preclinical models. Both animal models and 2D cell cultures of ACC fail to accurately mimic the disease, as animal physiology i...

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Detalles Bibliográficos
Autores principales: Dedhia, Priya H., Sivakumar, Hemamylammal, Rodriguez, Marco A., Nairon, Kylie G., Zent, Joshua M., Zheng, Xuguang, Jones, Katie, Popova, Liudmila V., Leight, Jennifer L., Skardal, Aleksander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509170/
https://www.ncbi.nlm.nih.gov/pubmed/37726363
http://dx.doi.org/10.1038/s41598-023-42659-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509170/
https://www.ncbi.nlm.nih.gov/pubmed/37726363
http://dx.doi.org/10.1038/s41598-023-42659-0

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