A probabilistic view of protein stability, conformational specificity, and design

Various approaches have used neural networks as probabilistic models for the design of protein sequences. These "inverse folding" models employ different objective functions, which come with trade-offs that have not been assessed in detail before. This study introduces probabilistic defini...

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Detalles Bibliográficos
Autores principales: Stern, Jacob A., Free, Tyler J., Stern, Kimberlee L., Gardiner, Spencer, Dalley, Nicholas A., Bundy, Bradley C., Price, Joshua L., Wingate, David, Della Corte, Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509192/
https://www.ncbi.nlm.nih.gov/pubmed/37726313
http://dx.doi.org/10.1038/s41598-023-42032-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509192/
https://www.ncbi.nlm.nih.gov/pubmed/37726313
http://dx.doi.org/10.1038/s41598-023-42032-1

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