Ser14 phosphorylation of Bcl-xL mediates compensatory cardiac hypertrophy in male mice

The anti-apoptotic function of Bcl-xL in the heart during ischemia/reperfusion is diminished by K-Ras-Mst1-mediated phosphorylation of Ser14, which allows dissociation of Bcl-xL from Bax and promotes cardiomyocyte death. Here we show that Ser14 phosphorylation of Bcl-xL is also promoted by hemodynam...

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Detalles Bibliográficos
Autores principales: Nakamura, Michinari, Keller, Mariko Aoyagi, Fefelova, Nadezhda, Zhai, Peiyong, Liu, Tong, Tian, Yimin, Ikeda, Shohei, Del Re, Dominic P., Li, Hong, Xie, Lai-Hua, Sadoshima, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509265/
https://www.ncbi.nlm.nih.gov/pubmed/37726310
http://dx.doi.org/10.1038/s41467-023-41595-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509265/
https://www.ncbi.nlm.nih.gov/pubmed/37726310
http://dx.doi.org/10.1038/s41467-023-41595-x

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