Essential role of the Pax5 C-terminal domain in controlling B cell commitment and development

The B cell regulator Pax5 consists of multiple domains whose function we analyzed in vivo by deletion in Pax5. While B lymphopoiesis was minimally affected in mice with homozygous deletion of the octapeptide or partial homeodomain, both sequences were required for optimal B cell development. Deletio...

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Detalles Bibliográficos
Autores principales: Gruenbacher, Sarah, Jaritz, Markus, Hill, Louisa, Schäfer, Markus, Busslinger, Meinrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509461/
https://www.ncbi.nlm.nih.gov/pubmed/37725138
http://dx.doi.org/10.1084/jem.20230260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509461/
https://www.ncbi.nlm.nih.gov/pubmed/37725138
http://dx.doi.org/10.1084/jem.20230260

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