Cargando…

Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells

Background: Resolving causal genes for type 2 diabetes at loci implicated by genome-wide association studies (GWAS) requires integrating functional genomic data from relevant cell types. Chromatin features in endocrine cells of the pancreatic islet are particularly informative and recent studies lev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Torres, Jason M., Sun, Han, Nylander, Vibe, Downes, Damien J., van de Bunt, Martijn, McCarthy, Mark I., Hughes, Jim R., Gloyn, Anna L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	F1000 Research Limited 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509606/ https://www.ncbi.nlm.nih.gov/pubmed/37736013 http://dx.doi.org/10.12688/wellcomeopenres.18653.2

Ejemplares similares

Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci
por: Thurner, Matthias, et al.
Publicado: (2018)

Evaluating the Performance of Fine-Mapping Strategies at Common Variant GWAS Loci
por: van de Bunt, Martijn, et al.
Publicado: (2015)

Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals
por: Wesolowska-Andersen, Agata, et al.
Publicado: (2020)

A Multi-omic Integrative Scheme Characterizes Tissues of Action at Loci Associated with Type 2 Diabetes
por: Torres, Jason M., et al.
Publicado: (2020)

Insights into islet development and biology through characterization of a human iPSC-derived endocrine pancreas model
por: van de Bunt, Martijn, et al.
Publicado: (2016)

Patterns of differential gene expression in a cellular model of human islet development, and relationship to type 2 diabetes predisposition
por: Perez-Alcantara, Marta, et al.
Publicado: (2018)

The miRNA Profile of Human Pancreatic Islets and Beta-Cells and Relationship to Type 2 Diabetes Pathogenesis
por: van de Bunt, Martijn, et al.
Publicado: (2013)

Prioritising Causal Genes at Type 2 Diabetes Risk Loci
por: Grotz, Antje K., et al.
Publicado: (2017)

Combining Mendelian randomization and network deconvolution for inference of causal networks with GWAS summary data
por: Lin, Zhaotong, et al.
Publicado: (2023)

Replication of chromosomal loci involved in Parkinson’s disease: A quantitative synthesis of GWAS
por: Rikos, Dimitrios, et al.
Publicado: (2021)

Exploiting the GTEx resources to decipher the mechanisms at GWAS loci
por: Barbeira, Alvaro N., et al.
Publicado: (2021)

Causal associations between risk factors and common diseases inferred from GWAS summary data
por: Zhu, Zhihong, et al.
Publicado: (2018)

Inferring causal direction between two traits in the presence of horizontal pleiotropy with GWAS summary data
por: Xue, Haoran, et al.
Publicado: (2020)

Robust inference of bi-directional causal relationships in presence of correlated pleiotropy with GWAS summary data
por: Xue, Haoran, et al.
Publicado: (2022)

Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data
por: Fernández-Tajes, Juan, et al.
Publicado: (2019)

The Contribution of GWAS Loci in Familial Dyslipidemias
por: Ripatti, Pietari, et al.
Publicado: (2016)

Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells
por: Hastoy, Benoît, et al.
Publicado: (2018)

An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci
por: Mountjoy, Edward, et al.
Publicado: (2021)

Identification of 90 NAFLD GWAS loci and establishment of NAFLD PRS and causal role of NAFLD in coronary artery disease
por: Miao, Zong, et al.
Publicado: (2021)

Long Non-Coding RNAs at the Chromosomal Risk Loci Identified by Prostate and Breast Cancer GWAS
por: Janaththani, Panchadsaram, et al.
Publicado: (2021)

Human islet function following 20 years of cryogenic biobanking
por: Manning Fox, Jocelyn E., et al.
Publicado: (2015)

Improved inference of chromosome conformation from images of labeled loci
por: Ross, Brian C., et al.
Publicado: (2019)

Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D
por: Viñuela, Ana, et al.
Publicado: (2020)

Quantifying Missing Heritability at Known GWAS Loci
por: Gusev, Alexander, et al.
Publicado: (2013)

GWAS reveals loci associated with velopharyngeal dysfunction
por: Chernus, Jonathan, et al.
Publicado: (2018)

Functional screens refine height GWAS loci
por: Ackert-Bicknell, Cheryl L.
Publicado: (2023)

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors
por: van de Bunt, Martijn, et al.
Publicado: (2015)

GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia
por: Chong, Michael, et al.
Publicado: (2022)

Blood cell traits’ GWAS loci colocalization with variation in PU.1 genomic occupancy prioritizes causal noncoding regulatory variants
por: Jeong, Raehoon, et al.
Publicado: (2023)

Re-sequencing Expands Our Understanding of the Phenotypic Impact of Variants at GWAS Loci
por: Service, Susan K., et al.
Publicado: (2014)

GWAS identifies four novel eosinophilic esophagitis loci
por: Sleiman, Patrick MA, et al.
Publicado: (2014)

Using Gene Expression to Annotate Cardiovascular GWAS Loci
por: Heinig, Matthias
Publicado: (2018)

Meta-GWAS for quantitative trait loci identification in soybean
por: Shook, Johnathon M, et al.
Publicado: (2021)

A Multi-tissue Transcriptome Analysis of Human Metabolites Guides Interpretability of Associations Based on Multi-SNP Models for Gene Expression
por: Ndungu, Anne, et al.
Publicado: (2020)

GWAS of Post-Orthodontic Aggressive External Apical Root Resorption Identified Multiple Putative Loci at X-Y Chromosomes
por: Iber-Díaz, Paula, et al.
Publicado: (2020)

Identifying loci with breeding potential across temperate and tropical adaptation via EigenGWAS and EnvGWAS
por: Li, Jing, et al.
Publicado: (2019)

TIGER: The gene expression regulatory variation landscape of human pancreatic islets
por: Alonso, Lorena, et al.
Publicado: (2021)

Dirichlet process model for joint haplotype inference and GWAS
por: Sahu, Avinash Das, et al.
Publicado: (2012)

Causal inference in econometrics
por: Huynh, Van-Nam, et al.
Publicado: (2016)

GWAS reveal novel IgA nephropathy risk loci
por: Foo, Jia Nee, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_9rmetphm86r79ko1hlibk0bmi4