Combined GLUT1 and OXPHOS inhibition eliminates acute myeloid leukemia cells by restraining their metabolic plasticity

Acute myeloid leukemia (AML) is initiated and propagated by leukemia stem cells (LSCs), a self-renewing population of leukemia cells responsible for therapy resistance. Hence, there is an urgent need to identify new therapeutic opportunities targeting LSCs. Here, we performed an in vivo CRISPR knock...

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Detalles Bibliográficos
Autores principales: Rodriguez-Zabala, Maria, Ramakrishnan, Ramprasad, Reinbach, Katrin, Ghosh, Somadri, Oburoglu, Leal, Falqués-Costa, Antoni, Bellamkonda, Kishan, Ehinger, Mats, Peña-Martínez, Pablo, Puente-Moncada, Noelia, Lilljebjörn, Henrik, Cammenga, Jörg, Pronk, Cornelis Jan, Lazarevic, Vladimir, Fioretos, Thoas, Hagström-Andersson, Anna K., Woods, Niels-Bjarne, Järås, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509671/
https://www.ncbi.nlm.nih.gov/pubmed/37505194
http://dx.doi.org/10.1182/bloodadvances.2023009967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509671/
https://www.ncbi.nlm.nih.gov/pubmed/37505194
http://dx.doi.org/10.1182/bloodadvances.2023009967

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