EP2 inhibition restores myeloid metabolism and reverses cognitive decline
Nonsteroidal anti-inflammatory drugs alleviate pain and inflammation by inhibiting the cyclooxygenase pathway. This pathway has various downstream effects, some of which are beneficial. Prostaglandin E(2) is a key downstream product in the cyclooxygenase pathway that modulates inflammation. A correl...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509962/ https://www.ncbi.nlm.nih.gov/pubmed/37780795 http://dx.doi.org/10.1016/j.jacig.2023.100082 |
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author | Lushington, Ryan Camilli, Samuel Pascual, Francisco Lockey, Richard F. Kolliputi, Narasaiah |
author_facet | Lushington, Ryan Camilli, Samuel Pascual, Francisco Lockey, Richard F. Kolliputi, Narasaiah |
author_sort | Lushington, Ryan |
collection | PubMed |
description | Nonsteroidal anti-inflammatory drugs alleviate pain and inflammation by inhibiting the cyclooxygenase pathway. This pathway has various downstream effects, some of which are beneficial. Prostaglandin E(2) is a key downstream product in the cyclooxygenase pathway that modulates inflammation. A correlation between aging and increased expression of the prostaglandin E(2) receptor, EP2, has been associated with inflammatory processes, cognitive aging, angiogenesis, and tumorigenesis. Therefore, inhibition of EP2 could lead to therapeutic effects and be more selective than inhibiting cyclooxygenase-2. Studies suggest that inhibition of EP2 restores age-associated spatial memory deficits and synaptic proteins and impairs tumorigenesis. The data indicate that EP2 signaling is important in myeloid cell metabolism and support its candidacy as a therapeutic target. |
format | Online Article Text |
id | pubmed-10509962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-105099622023-09-29 EP2 inhibition restores myeloid metabolism and reverses cognitive decline Lushington, Ryan Camilli, Samuel Pascual, Francisco Lockey, Richard F. Kolliputi, Narasaiah J Allergy Clin Immunol Glob Rostrum Nonsteroidal anti-inflammatory drugs alleviate pain and inflammation by inhibiting the cyclooxygenase pathway. This pathway has various downstream effects, some of which are beneficial. Prostaglandin E(2) is a key downstream product in the cyclooxygenase pathway that modulates inflammation. A correlation between aging and increased expression of the prostaglandin E(2) receptor, EP2, has been associated with inflammatory processes, cognitive aging, angiogenesis, and tumorigenesis. Therefore, inhibition of EP2 could lead to therapeutic effects and be more selective than inhibiting cyclooxygenase-2. Studies suggest that inhibition of EP2 restores age-associated spatial memory deficits and synaptic proteins and impairs tumorigenesis. The data indicate that EP2 signaling is important in myeloid cell metabolism and support its candidacy as a therapeutic target. Elsevier 2023-02-08 /pmc/articles/PMC10509962/ /pubmed/37780795 http://dx.doi.org/10.1016/j.jacig.2023.100082 Text en © 2023 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Rostrum Lushington, Ryan Camilli, Samuel Pascual, Francisco Lockey, Richard F. Kolliputi, Narasaiah EP2 inhibition restores myeloid metabolism and reverses cognitive decline |
title | EP2 inhibition restores myeloid metabolism and reverses cognitive decline |
title_full | EP2 inhibition restores myeloid metabolism and reverses cognitive decline |
title_fullStr | EP2 inhibition restores myeloid metabolism and reverses cognitive decline |
title_full_unstemmed | EP2 inhibition restores myeloid metabolism and reverses cognitive decline |
title_short | EP2 inhibition restores myeloid metabolism and reverses cognitive decline |
title_sort | ep2 inhibition restores myeloid metabolism and reverses cognitive decline |
topic | Rostrum |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509962/ https://www.ncbi.nlm.nih.gov/pubmed/37780795 http://dx.doi.org/10.1016/j.jacig.2023.100082 |
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