EP2 inhibition restores myeloid metabolism and reverses cognitive decline

Nonsteroidal anti-inflammatory drugs alleviate pain and inflammation by inhibiting the cyclooxygenase pathway. This pathway has various downstream effects, some of which are beneficial. Prostaglandin E(2) is a key downstream product in the cyclooxygenase pathway that modulates inflammation. A correl...

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Autores principales: Lushington, Ryan, Camilli, Samuel, Pascual, Francisco, Lockey, Richard F., Kolliputi, Narasaiah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509962/
https://www.ncbi.nlm.nih.gov/pubmed/37780795
http://dx.doi.org/10.1016/j.jacig.2023.100082
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author Lushington, Ryan
Camilli, Samuel
Pascual, Francisco
Lockey, Richard F.
Kolliputi, Narasaiah
author_facet Lushington, Ryan
Camilli, Samuel
Pascual, Francisco
Lockey, Richard F.
Kolliputi, Narasaiah
author_sort Lushington, Ryan
collection PubMed
description Nonsteroidal anti-inflammatory drugs alleviate pain and inflammation by inhibiting the cyclooxygenase pathway. This pathway has various downstream effects, some of which are beneficial. Prostaglandin E(2) is a key downstream product in the cyclooxygenase pathway that modulates inflammation. A correlation between aging and increased expression of the prostaglandin E(2) receptor, EP2, has been associated with inflammatory processes, cognitive aging, angiogenesis, and tumorigenesis. Therefore, inhibition of EP2 could lead to therapeutic effects and be more selective than inhibiting cyclooxygenase-2. Studies suggest that inhibition of EP2 restores age-associated spatial memory deficits and synaptic proteins and impairs tumorigenesis. The data indicate that EP2 signaling is important in myeloid cell metabolism and support its candidacy as a therapeutic target.
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spelling pubmed-105099622023-09-29 EP2 inhibition restores myeloid metabolism and reverses cognitive decline Lushington, Ryan Camilli, Samuel Pascual, Francisco Lockey, Richard F. Kolliputi, Narasaiah J Allergy Clin Immunol Glob Rostrum Nonsteroidal anti-inflammatory drugs alleviate pain and inflammation by inhibiting the cyclooxygenase pathway. This pathway has various downstream effects, some of which are beneficial. Prostaglandin E(2) is a key downstream product in the cyclooxygenase pathway that modulates inflammation. A correlation between aging and increased expression of the prostaglandin E(2) receptor, EP2, has been associated with inflammatory processes, cognitive aging, angiogenesis, and tumorigenesis. Therefore, inhibition of EP2 could lead to therapeutic effects and be more selective than inhibiting cyclooxygenase-2. Studies suggest that inhibition of EP2 restores age-associated spatial memory deficits and synaptic proteins and impairs tumorigenesis. The data indicate that EP2 signaling is important in myeloid cell metabolism and support its candidacy as a therapeutic target. Elsevier 2023-02-08 /pmc/articles/PMC10509962/ /pubmed/37780795 http://dx.doi.org/10.1016/j.jacig.2023.100082 Text en © 2023 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Rostrum
Lushington, Ryan
Camilli, Samuel
Pascual, Francisco
Lockey, Richard F.
Kolliputi, Narasaiah
EP2 inhibition restores myeloid metabolism and reverses cognitive decline
title EP2 inhibition restores myeloid metabolism and reverses cognitive decline
title_full EP2 inhibition restores myeloid metabolism and reverses cognitive decline
title_fullStr EP2 inhibition restores myeloid metabolism and reverses cognitive decline
title_full_unstemmed EP2 inhibition restores myeloid metabolism and reverses cognitive decline
title_short EP2 inhibition restores myeloid metabolism and reverses cognitive decline
title_sort ep2 inhibition restores myeloid metabolism and reverses cognitive decline
topic Rostrum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509962/
https://www.ncbi.nlm.nih.gov/pubmed/37780795
http://dx.doi.org/10.1016/j.jacig.2023.100082
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