Combined inhibition of Bcl-2 family members and YAP induces synthetic lethality in metastatic gastric cancer with RASA1 and NF2 deficiency

BACKGROUND: Targetable molecular drivers of gastric cancer (GC) metastasis remain largely unidentified, leading to limited targeted therapy options for advanced GC. We aimed to identify molecular drivers for metastasis and devise corresponding therapeutic strategies. METHODS: We performed an unbiase...

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Detalles Bibliográficos
Autores principales: Kwon, Jong-Wan, Oh, Jeong-Seop, Seok, Sang Hyeok, An, Hyeok-Won, Lee, Yu Jin, Lee, Na Yun, Ha, Taehun, Kim, Hyeon Ah, Yoon, Gyeong Min, Kim, Sung Eun, Oh, Pu-Reum, Lee, Su-Hyung, Voon, Dominic C., Kim, Dae-Yong, Park, Jun Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510129/
https://www.ncbi.nlm.nih.gov/pubmed/37730636
http://dx.doi.org/10.1186/s12943-023-01857-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510129/
https://www.ncbi.nlm.nih.gov/pubmed/37730636
http://dx.doi.org/10.1186/s12943-023-01857-0

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