The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus

BACKGROUND: The risk for dementia increases exponentially from the seventh decade of life. Identifying and understanding the biochemical changes that sensitize the ageing brain to neurodegeneration will provide new opportunities for dementia prevention and treatment. This study aimed to determine ho...

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Detalles Bibliográficos
Autores principales: Lee, Jun Yup, Harney, Dylan J, Teo, Jonathan D, Kwok, John B, Sutherland, Greg T., Larance, Mark, Don, Anthony S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510131/
https://www.ncbi.nlm.nih.gov/pubmed/37726834
http://dx.doi.org/10.1186/s13024-023-00650-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510131/
https://www.ncbi.nlm.nih.gov/pubmed/37726834
http://dx.doi.org/10.1186/s13024-023-00650-3

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