Cargando…

The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus

BACKGROUND: The risk for dementia increases exponentially from the seventh decade of life. Identifying and understanding the biochemical changes that sensitize the ageing brain to neurodegeneration will provide new opportunities for dementia prevention and treatment. This study aimed to determine ho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Jun Yup, Harney, Dylan J, Teo, Jonathan D, Kwok, John B, Sutherland, Greg T., Larance, Mark, Don, Anthony S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510131/ https://www.ncbi.nlm.nih.gov/pubmed/37726834 http://dx.doi.org/10.1186/s13024-023-00650-3

Ejemplares similares

The major TMEM106B dementia risk allele affects TMEM106B protein levels and myelin lipid homeostasis in the ageing human hippocampus
por: Lee, Jun Yup, et al.
Publicado: (2023)

Identification of TMEM106B amyloid fibrils provides an updated view of TMEM106B biology in health and disease
por: Perneel, Jolien, et al.
Publicado: (2022)

C-terminal TMEM106B fragments in human brain correlate with disease-associated TMEM106B haplotypes
por: T. Vicente, Cristina, et al.
Publicado: (2023)

Lysosomal TMEM106B interacts with galactosylceramidase to regulate myelin lipid metabolism
por: Takahashi, Hideyuki, et al.
Publicado: (2023)

Antibody-recognizing residues 188-211 of TMEM106B exhibit immunohistochemical reactivity with the TMEM106B C-terminal fragment
por: Ishikawa, Ruoyi, et al.
Publicado: (2023)

Variation in TMEM106B in chronic traumatic encephalopathy
por: Cherry, Jonathan D., et al.
Publicado: (2018)

Lysosomal dysfunction in TMEM106B hypomyelinating leukodystrophy
por: Ito, Yoko, et al.
Publicado: (2018)

TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss
por: Feng, Tuancheng, et al.
Publicado: (2022)

TMEM106B expression is reduced in Alzheimer’s disease brains
por: Satoh, Jun-ichi, et al.
Publicado: (2014)

TMEM106B aggregation in neurodegenerative diseases: linking genetics to function
por: Jiao, Hai-Shan, et al.
Publicado: (2023)

TMEM106B regulates microglial proliferation and survival in response to demyelination
por: Zhang, Tingting, et al.
Publicado: (2023)

Generic amyloid fibrillation of TMEM106B in patient with Parkinson’s disease dementia and normal elders
por: Fan, Yun, et al.
Publicado: (2022)

The identification of high-performing antibodies for transmembrane protein 106B (TMEM106B) for use in Western blot, immunoprecipitation, and immunofluorescence
por: Ayoubi, Riham, et al.
Publicado: (2023)

TMEM106B a Novel Risk Factor for Frontotemporal Lobar Degeneration
por: van der Zee, Julie, et al.
Publicado: (2011)

Age-dependent formation of TMEM106B amyloid filaments in human brains
por: Schweighauser, Manuel, et al.
Publicado: (2022)

TMEM106A transcriptionally regulated by promoter methylation is involved in invasion and metastasis of hepatocellular carcinoma: TMEM106A is involved in invasion and metastasis of HCC
por: Shi, Shiming, et al.
Publicado: (2022)

TMEM106B haplotypes have distinct gene expression patterns in aged brain
por: Ren, Yingxue, et al.
Publicado: (2018)

Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency
por: Arrant, Andrew E., et al.
Publicado: (2018)

A novel, potentially targetable TMEM106B-BRAF fusion in pleomorphic xanthoastrocytoma
por: Hsiao, Susan J., et al.
Publicado: (2017)

Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice
por: Feng, Tuancheng, et al.
Publicado: (2020)

Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits
por: Rademakers, Rosa, et al.
Publicado: (2021)

The TMEM106B risk allele is associated with lower cortical volumes in a clinically diagnosed frontotemporal dementia cohort
por: Harding, Sophie R, et al.
Publicado: (2017)

LATE-NC risk alleles (in TMEM106B, GRN, and ABCC9 genes) among persons with African ancestry
por: Katsumata, Yuriko, et al.
Publicado: (2023)

TMEM106B is associated with frontotemporal lobar degeneration in a clinically diagnosed patient cohort
por: van der Zee, Julie, et al.
Publicado: (2011)

Loss of TMEM106B potentiates lysosomal and FTLD‐like pathology in progranulin‐deficient mice
por: Werner, Georg, et al.
Publicado: (2020)

TMEM106B Acts as a Modifier of Cognitive and Motor Functions in Amyotrophic Lateral Sclerosis
por: Manini, Arianna, et al.
Publicado: (2022)

TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins
por: Kundu, Samrat T., et al.
Publicado: (2018)

Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain
por: Busch, Johanna I, et al.
Publicado: (2013)

TMEM106B, a risk factor for FTLD and aging, has an intrinsically disordered cytoplasmic domain
por: Kang, Jian, et al.
Publicado: (2018)

Severe Epilepsy and Movement Disorder May Be Early Symptoms of TMEM106B-Related Hypomyelinating Leukodystrophy
por: Solazzi, Roberta, et al.
Publicado: (2022)

Case report: TMEM106B haplotype alters penetrance of GRN mutation in frontotemporal dementia family
por: Perneel, Jolien, et al.
Publicado: (2023)

TMEM106C contributes to the malignant characteristics and poor prognosis of hepatocellular carcinoma
por: Duan, Jicheng, et al.
Publicado: (2021)

TMEM106A inhibits enveloped virus release from cell surface
por: Mao, Dexin, et al.
Publicado: (2022)

Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown
por: Clayton, Emma L, et al.
Publicado: (2018)

Elevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiency
por: Zhou, Xiaolai, et al.
Publicado: (2017)

rs1990622 variant associates with Alzheimer’s disease and regulates TMEM106B expression in human brain tissues
por: Hu, Yang, et al.
Publicado: (2021)

Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation
por: Bauer, Claudia S., et al.
Publicado: (2022)

Identification of a de novo Mutation in TMEM106B in a Saudi Child Causes Hypomyelination Leukodystrophy
por: Alotaibi, Lena, et al.
Publicado: (2023)

The TMEM106B T186S coding variant increases neurite arborization and synaptic density in primary hippocampal neurons
por: Nguyen, Quynh, et al.
Publicado: (2023)

Cognitive reserve and TMEM106B genotype modulate brain damage in presymptomatic frontotemporal dementia: a GENFI study
por: Premi, Enrico, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_mvfg24gun1ih9rq4enui1h40od