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Novel multi-objective affinity approach allows to identify pH-specific μ-opioid receptor agonists
Opioids are essential pharmaceuticals due to their analgesic properties, however, lethal side effects, addiction, and opioid tolerance are extremely challenging. The development of novel molecules targeting the [Formula: see text] -opioid receptor (MOR) in inflamed, but not in healthy tissue, could...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510211/ https://www.ncbi.nlm.nih.gov/pubmed/37726792 http://dx.doi.org/10.1186/s13321-023-00746-4 |