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Novel multi-objective affinity approach allows to identify pH-specific μ-opioid receptor agonists

Opioids are essential pharmaceuticals due to their analgesic properties, however, lethal side effects, addiction, and opioid tolerance are extremely challenging. The development of novel molecules targeting the [Formula: see text] -opioid receptor (MOR) in inflamed, but not in healthy tissue, could...

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Detalles Bibliográficos
Autores principales:	Secker, Christopher, Fackeldey, Konstantin, Weber, Marcus, Ray, Sourav, Gorgulla, Christoph, Schütte, Christof
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510211/ https://www.ncbi.nlm.nih.gov/pubmed/37726792 http://dx.doi.org/10.1186/s13321-023-00746-4

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