Alkyne as a Latent Warhead to Covalently Target SARS-CoV-2 Main Protease

[Image: see text] There is an urgent need for improved therapy to better control the ongoing COVID-19 pandemic. The main protease M(pro) plays a pivotal role in SARS-CoV-2 replications, thereby representing an attractive target for antiviral development. We seek to identify novel electrophilic warhe...

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Detalles Bibliográficos
Autores principales: Ngo, Chau, Fried, William, Aliyari, Saba, Feng, Joshua, Qin, Chao, Zhang, Shilei, Yang, Hanjing, Shanaa, Jean, Feng, Pinghui, Cheng, Genhong, Chen, Xiaojiang S., Zhang, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510381/
https://www.ncbi.nlm.nih.gov/pubmed/37595260
http://dx.doi.org/10.1021/acs.jmedchem.3c00810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510381/
https://www.ncbi.nlm.nih.gov/pubmed/37595260
http://dx.doi.org/10.1021/acs.jmedchem.3c00810

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