Development of a Selective Peptide κ-Opioid Receptor Antagonist by Late-Stage Functionalization with Cysteine Staples

[Image: see text] The κ-opioid receptor (KOR) is an attractive target for the development of novel drugs. KOR agonists are potentially safer pain medications, whereas KOR antagonists are promising drug candidates for the treatment of neuropsychiatric disorders. Hitherto, the vast majority of selecti...

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Detalles Bibliográficos
Autores principales: Muratspahić, Edin, White, Andrew M., Ciotu, Cosmin I., Hochrainer, Nadine, Tomašević, Nataša, Koehbach, Johannes, Lewis, Richard J., Spetea, Mariana, Fischer, Michael J. M., Craik, David J., Gruber, Christian W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510397/
https://www.ncbi.nlm.nih.gov/pubmed/37632447
http://dx.doi.org/10.1021/acs.jmedchem.3c00426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510397/
https://www.ncbi.nlm.nih.gov/pubmed/37632447
http://dx.doi.org/10.1021/acs.jmedchem.3c00426

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