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The nuclear receptor LRH‐1 discriminates between ligands using distinct allosteric signaling circuits
Nuclear receptors (NRs) are transcription factors that regulate essential biological processes in response to cognate ligands. An important part of NR function involves ligand‐induced conformational changes that recruit coregulator proteins to the activation function surface (AFS), ~15 Å away from t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510465/ https://www.ncbi.nlm.nih.gov/pubmed/37572334 http://dx.doi.org/10.1002/pro.4754 |