Allosteric site variants affect GTP hydrolysis on Ras

RAS GTPases are proto‐oncoproteins that regulate cell growth, proliferation, and differentiation in response to extracellular signals. The signaling functions of RAS, and other small GTPases, are dependent on their ability to cycle between GDP‐bound and GTP‐bound states. Structural analyses suggest...

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Detalles Bibliográficos
Autores principales: Johnson, Christian W., Fetics, Susan K., Davis, Kathleen P., Rodrigues, Jose A., Mattos, Carla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510474/
https://www.ncbi.nlm.nih.gov/pubmed/37615343
http://dx.doi.org/10.1002/pro.4767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510474/
https://www.ncbi.nlm.nih.gov/pubmed/37615343
http://dx.doi.org/10.1002/pro.4767

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